Scientist Profile
















Details of Research Publications (National + International)

Author Names Topic Journal Name Volume Number Issue Number Page Number Year Published Impact Factor
Gage M, Yuldasheva N, Viswambharan H, Sukumar P, Cubbon R, Imrie H, Abbas A, Smith J, Kahn M, Wheatcroft SB & Kearney MT Endothelium-specific insulin resistance leads to accelerated atherosclerosis in areas with disturbed flow patterns: a role for reactive oxygen species. Atherosclerosis 230 1 131-139 2013
Sukumar P, Viswambharan H, Imrie H, Cubbon RM, Yuldeshava N,Gage M, Galloway S, Skromna A , Kandavelu P, Santos C-X, Gatenby VK, Smith J, Beech DJ, Wheatcroft SB, Channon KM, Shah AM & Kearney MT. Role of NADPH oxidase in endothelial dysfunction Diabetes 62 6 2130-2134 2013
Imrie H, Viswambharan H, Sukumar P, Abbas, A, Cubbon RM, Yuldeshava N, Gage M, Smith J, Galloway S, Skromna A, Rashid ST, Futers S, Xuan S, Gatenby VK, Grant PJ, Channon KM, Beech DJ, Wheatcroft SB & Kearney MT Novel Role of the IGF-1 receptor in endothelial cell function and repair: studies in endothelium-targeted IGF-1R transgenic mice. Diabetes 61 9 2359-2368 2012
Sukumar P, Sedo A, Li J, Wilson LA, O'Regan D, Lippiat JD, Porter KE, Kearney MT, Ainscough JF & Beech DJ Constitutively active TRPC channels of adipocytes confer a mechanism for sensing dietary fatty acids and regulating adiponectin. Circulation Research 111 2 191-200 2012
Rajwani A, Ezzat V, Smith J, Yuldasheva N, Duncan N, Gage M, Cubbon RM, Kahn MB, Imrie H, Abbas A, Viswambharan H, Aziz A,Sukumar P, Vidal-Puig A, Sethi JK, Xuan S, Shah AM, Grant PJ, Porter KE, Kearney MT & Wheatcroft SB Increasing circulating IGFBP1 levels improves insulin-sensitivity, promotes nitric oxide production, lowers blood pressure and protects against atherosclerosis. Diabetes 61 4 915-924 2012
Abbas A, Imrie H, Viswambharan H, Sukumar P, Rajwani A, Cubbon RM, Gage M, Smith J, Galloway S, Yuldeshava N, Kahn M, Xuan S, Grant PJ, Channon KM, Beech DJ, Wheatcroft SB & Kearney MT The insulin-like growth factor-1 receptor is a negative regulator of nitric oxide bioavailability and insulin sensitivity in the endothelium. Diabetes 60 8 2169-2178 2011
Majeed Y, Bahnasi Y, Seymour VA, Wilson LA, Milligan CJ, Agarwal AK, Sukumar P, Naylor J & Beech DJ Rapid and contrasting effects of rosiglitazone on transient receptor potential TRPM3 and TRPC5 channels. Molecular Pharmacology 79 6 1023-1030 2011
Kahn MB, Yuldasheva NY, Cubbon RM, Smith J, Rashid ST, Viswambharan H, Imrie H, Abbas A, Rajwani A, Baliga V, Sukumar P, Gage M, Kearney MT & Wheatcroft SB Insulin resistance impairs circulating angiogenic progenitor cell function & delays endothelial regeneration. Diabetes 60 4 1295-1303 2011
Cheong A, Li J, Sukumar P, Kumar B, Zeng F, Riches K, Munsch C, Wood IC, Porter KE & Beech DJ. Potent suppression of vascular smooth muscle cell migration and human neointimal hyperplasia by KV1.3 channel blockers. Cardiovascular Research 89 2 282-289 2011
Ciurtin C, Majeed Y, Naylor J, Sukumar P, English AA, Emery P & Beech DJ TRPM3 channel stimulated by pregnenolone sulphate in synovial fibroblasts and negatively coupled to hyaluronan. BMC Musculoskeletal Disorders 11 111 2010
Wong CO, *Sukumar P, Beech DJ & Yao X Nitric oxide lacks direct effect on TRPC5 channels but suppresses endogenous TRPC5-containing channels in endothelial cells. Pflugers Archive 460 1 121-130 2010
Naylor J, Li J, Milligan CJ, Zeng F, Sukumar P, Hou B, Sedo A, Yuldasheva N, Majeed Y, Beri D, Jiang S, Seymour VA, McKeown L, Kumar B, Harteneck C, O'Regan D, Wheatcroft SB, Kearney MT, Jones C, Porter KE & Beech DJ Pregnenolone sulphate- and cholesterol-regulated TRPM3 channels coupled to vascular smooth muscle secretion and contraction. Circulation Research 106 9 1507-1515 2010
Sukumar P & Beech DJ Stimulation of TRPC5 cationic channels by low micromolar concentrations of lead ions (Pb2+). Biochemical and Biophysical Research Communications 393 1 50-54 2010
Milligan CJ, Li J., Sukumar P, Majeed Y, Dallas M, English A, Emery P, Porter KE, Smith AM, McFadzean I, Beccano-Kelly D, Bahnasi YM, Cheong A, Naylor J, Zeng F, Liu X, Gamper N, Jiang LH, Pearson HA, Peers C, Robertson B & Beech DJ Robotic multi-well planar patch-clamp for native and primary mammalian cells. Nature Protocols 4 2 244-255 2009
Li J, Sukumar P, Milligan CJ, Kumar B, Ma Z, Munsch CM, Jiang LH, Porter KE & Beech DJ Interactions, functions and independence of plasma membrane STIM1 and TRPC1 in vascular smooth muscle cells. Circulation Research 103 8 97-104 2008
Xu SZ, *Sukumar P, Zeng F, Li J, Jairaman A, English A, Naylor J, Ciurtin C, Majeed Y, Milligan CJ, Bahnasi YM, AL-Shawaf E, Porter KE, Jiang LH, Emery P, Sivaprasadarao A & Beech DJ. TRP channel activation by extracellular thioredoxin. Nature 451 69-72 2008
Beech DJ & Sukumar P Channel regulation by extracellular redox protein. Channels 1 6 400-403 2007
Xu SZ, *Muraki K, *Zeng F, *Li J, *Sukumar P, Shah S, Dedman A.M, Flemming PK, Naylor J, Cheong A, Bateson AN, Porter KE, Munsch CM & Beech DJ A sphingosine-1-phosphate activated calcium channel controlling vascular smooth muscle cell motility. Circulation Research 98 11 1381-1389 2006
Kumar B, Dreja K, Shah S, Cheong A, Xu S.Z, Sukumar P, Naylor J, Forte A, Cipollaro M, McHugh D, Kingston P, Heagerty AM, Munsch CM, Bergdahl A, Hultgardh-Nilsson A, Gomez MF, Porter KE, Hellstrand P, & Beech DJ Up-regulated TRPC1 channel in vascular injury in vivo and its role in human neointimal hyperplasia. Circulation Research 98 4 557-563 2006
Cheong A, Bingham AJ, Li J, Kumar B, Sukumar P, Munsch CM, Buckley NJ, Neylon CB, Porter KE, Beech DJ & Wood I.C Down-regulated REST transcription factor is a switch enabling critical potassium channel expression and cell proliferation. Molecular Cell 20 45-52 2005

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Nucleotide Sequence

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